PoTS can be triggered by a number of factors. However, scientists believe viruses such as SARS-CoV-2 or bacteria seem to trigger this condition most often. Coronavirus can lead to PoTS and some people who recovered from COVID-19 had PoTS-like symptoms. These symptoms include faster heart rate with slight increase in activity, brain fog, lightheadedness, headaches, nausea, vomiting and severe chronic fatigue.